Ascariasis: Introduction, pathogenesis, diagnosis, prevention and control

Introduction: Ascaris lumbricoides belongs to class Phasmida of Phylum Aschelminthes or Nemathelminthes. It is commonly called a roundworm, attributed to its worm-like morphology. Because A. lumbricoides eggs can withstand a variety of environmental circumstances, a large number of eggs are generated per female worm, and inadequate sanitary conditions are common, particularly in developing and undeveloped […]

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Comprehensive Guide to Organizing a Clinical Microbiology Laboratory: Design, Management, and ISO 15189 Compliance

Introduction to Clinical Microbiology Laboratory Organization: A clinical microbiology lab performs analytical tests on human body substances for disease diagnosis, prevention and aids patient management for promotion of good health. Organization means an orderly structure making arrangements for achievement of purpose. In microbiology lab, the purpose is clinical relevance i.e., promotion of patient’s health.  Key

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Protein Secretion in Bacteria: Introduction, Sec and Tat Pathways, Signal Recognition Particle (SRP) Pathway

Introduction to Protein Secretion in Bacteria: Like all other organisms, bacteria have all the necessary cell structures that ensure their survival and proper functioning. The protective cell envelope can be two or three membranes, depending on the nature of the bacteria. Bacteria are protected from the environment by one or two membranes that prevent the

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Conventional and rapid methods in the laboratory diagnosis of pyrexia of unknown origin

Introduction to Pyrexia of Unknown Origin (PUO): Pyrexia of unknown origin (PUO) is a temperature above 38.3 degrees Celsius, lasting more than 3 weeks, and there is failure to reach a diagnosis despite a week of inpatient investigation.  PUO could be classic PUO (temperature >38.3 degrees Celsius for more than 3 weeks and evaluation of

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Biosecurity and Biosafety: Framework, Levels, Protocols, and Regulations

Introduction to Biosecurity and Biosafety: Biosecurity is the prevention of misuse, loss, theft and unauthorized access, and intentional release of harmful agents like pathogens, their toxins, and the equipment involved in doing so. The Biological and Toxin Weapons Convention was formed in 1975 to address the bad use of bioweapons. The biosecurity functions are at

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Bacterial invasion into the host: Zipper and Trigger mechanism

Introduction and overview of bacterial invasion: Living inside host cells helps bacterial pathogens to exploit the intracellular niche and nutrient-rich environment. Many pathogenic bacteria employ phagocytosis to enter the host cell. After entering the cells, these bacteria block phagolysosome formation, preventing lysis of the self. This conceals the bacteria from host defense. To infiltrate the

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Type II Hypersensitivity Reactions: Introduction, Mechanisms, Clinical Manifestations Blood Transfusion Reactions, Hemolytic Disease of the Newborn

Introduction to Hypersensitivity Reactions: When an individual has been immunologically primed, further contact with the antigen leads to a secondary immune response, boosting. However, if the antigen is present in relatively large amounts or if the humoral and cellular immune state is at a heightened level, the reaction may be excessive and may lead to

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2 HIV Vaccine Trials Show Proof of Concept for Pathway to Broadly Neutralizing Antibodies

Determining how to teach the immune system to generate antibodies that can target many virus variations has been a major difficulty in the development of HIV vaccines for decades. Because HIV mutates quickly and conceals important aspects of itself from the immune system, traditional methods haven’t worked. https://www.clinicallab.com/2-hiv-vaccine-trials-show-proof-of-concept-for-pathway-to-broadly-neutralizing-antibodies-28286

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Comparative Morphology and Life Cycle of Taenia solium and Taenia saginata: Key Differences and Similarities

Introduction: Tapeworms (Taenia solium and Taenia saginata) belong to the class Cestoda of phylum Platyhelminthes. Tapeworms are flat, parasitic animals with complex life cycles that infect animals, including humans. They are exclusively endoparasites. Comparison and contrast of Taenia solium and Taenia saginata in terms of morphology: Differences between Taenia solium and Taenia saginata: Differences in

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Molecular Tools for Microbial Taxonomy and Phylogenetic Studies

Introduction: Some of the most powerful approaches to determine the taxonomy and phylogeny of the organisms is through the study of nucleic acids and proteins, since they are genes themselves or direct gene products that provide considerable information about the true relatedness. Phylogenetic inferences based on molecular tools characterization provide the strongest and most reliable

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