Biosecurity and Biosafety: Framework, Levels, Protocols, and Regulations

Introduction to Biosecurity and Biosafety: Biosecurity is the prevention of misuse, loss, theft and unauthorized access, and intentional release of harmful agents like pathogens, their toxins, and the equipment involved in doing so. The Biological and Toxin Weapons Convention was formed in 1975 to address the bad use of bioweapons. The biosecurity functions are at […]

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Bacterial invasion into the host: Zipper and Trigger mechanism

Introduction and overview of bacterial invasion: Living inside host cells helps bacterial pathogens to exploit the intracellular niche and nutrient-rich environment. Many pathogenic bacteria employ phagocytosis to enter the host cell. After entering the cells, these bacteria block phagolysosome formation, preventing lysis of the self. This conceals the bacteria from host defense. To infiltrate the

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Type II Hypersensitivity Reactions: Introduction, Mechanisms, Clinical Manifestations Blood Transfusion Reactions, Hemolytic Disease of the Newborn

Introduction to Hypersensitivity Reactions: When an individual has been immunologically primed, further contact with the antigen leads to a secondary immune response, boosting. However, if the antigen is present in relatively large amounts or if the humoral and cellular immune state is at a heightened level, the reaction may be excessive and may lead to

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2 HIV Vaccine Trials Show Proof of Concept for Pathway to Broadly Neutralizing Antibodies

Determining how to teach the immune system to generate antibodies that can target many virus variations has been a major difficulty in the development of HIV vaccines for decades. Because HIV mutates quickly and conceals important aspects of itself from the immune system, traditional methods haven’t worked. https://www.clinicallab.com/2-hiv-vaccine-trials-show-proof-of-concept-for-pathway-to-broadly-neutralizing-antibodies-28286

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Comparative Morphology and Life Cycle of Taenia solium and Taenia saginata: Key Differences and Similarities

Introduction: Tapeworms (Taenia solium and Taenia saginata) belong to the class Cestoda of phylum Platyhelminthes. Tapeworms are flat, parasitic animals with complex life cycles that infect animals, including humans. They are exclusively endoparasites. Comparison and contrast of Taenia solium and Taenia saginata in terms of morphology: Differences between Taenia solium and Taenia saginata: Differences in

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Molecular Tools for Microbial Taxonomy and Phylogenetic Studies

Introduction: Some of the most powerful approaches to determine the taxonomy and phylogeny of the organisms is through the study of nucleic acids and proteins, since they are genes themselves or direct gene products that provide considerable information about the true relatedness. Phylogenetic inferences based on molecular tools characterization provide the strongest and most reliable

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Novel Methods for the Laboratory Diagnosis of Helminthic Infections

Introduction: Helminthes, including Nematodes, Trematodes, and Cestodes, are associated with substantial morbidity and economic losses worldwide. Almost one-sixth of the world’s population is infected with helminthes, with an estimated 15 billion individuals, particularly in low socio-economic regions, suffering from Soil-transmitted Helminthes (STHs). Novel techniques are now being developed and tested for the diagnosis of helminthic

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Bacterial Pneumonia: Etiology, Risk Factors, and Diagnosis

Introduction: Lower respiratory tract infections are the most common human infections, estimated to cause 2.74 million deaths annually. LRTIs are diverse and can present as tracheitis, bronchitis, bronchiolitis and pneumonia. Community Acquired Pneumonia (CAP) is the one that is contracted outside hospital settings. Hospital-Acquired Pneumonia (HAP) is the infection of the lungs whose evidence was

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Zika Virus (ZIKV): Introduction, Transmission and Diagnosis

Introduction to Zika Virus and Vector-Borne Diseases: Emergence and re-emergence of Vector Borne Diseases (VBD) have posed a huge threat to public health worldwide. Flaviviruses like Dengue Virus (DENV), Yellow Fever Virus (YFV), and Japanese Encephalitis Virus (JEV) are already circulating globally. Since the vectors, transmission cycle, favorable climate, and epidemiology of Zika virus (ZIKV)

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Autoimmunity: Introduction, Mechanisms, Examples, and Treatment

Introduction: An inappropriate response of the immune system leading to activation of self-reactive humoral or cell-mediated responses against self-antigens are called autoimmunity. Autoimmune conditions that involve direct damage to cells occur when antibodies or immune cells attach to antigens on the surface of cells. This interaction can lead to cell destruction or provoke inflammation in

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