Molecular basis of cancer: Oncogene,  Tumor suppressor Genes, Carcinogenesis, Mechanism of Action of Oncogenes

Mechanism of induction of cancer: It is a gradual multistep process involving many generations of cells. The cancer cells are genetically and phenotypically transformed cells having phenotypic features of malignancy like excessive growth, invasiveness, and distant metastasis. Normal cell growth is genetically controlled by four different types of regulatory control genes. The abnormality in these […]

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Tumor Suppressor Genes and Oncogenes: Introduction, p53 gene, RB gene and Two hit Hypothesis

Tumor suppressor Genes: Introduction Tumor suppressor genes code for protein which function to control cell division and ensure that it only occurs when necessary. It is also recognized as a guardian of gene. Tumor suppressor genes code for proteins involved in preventing cell cycle progression known as gate keepers and proteins involved in repairing DNA

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Isolation of Mitochondria

Aim: To isolate mitochondria from the given sample Objective: The isolation of mitochondria is useful in order to study and explore fundamental processes including mitochondrial respiration, metabolic activity, protein import, membrane fusion, protein complex assembly, as well as interactions of mitochondria with the cytoskeleton, nuclear encoded mRNAs, and other organelles.  Principle: The nucleus has two

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Cell cycle, Checkpoints, Cyclins and Its Types: Introduction, External and Internal signals of cell cycle control

Introduction to Cell Cycle Regulation: Cell division is a very crucial phenomenon for normal growth, development and maintenance. But in a body of eukaryotes organisms such as humans, the rate of timing of cell division varies on the type of cells. For e.g., skin cells divide frequently throughout life time. However, specialized cells such as

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Surgery in cancer patient: Introduction, Types of surgery, Minimally Invasive Surgery (MIS)

Introduction: A team of professionals, including an oncologist, surgeon, and pathologist, work together to make the best diagnosis and treatment decisions for cancer patients. Surgery is the removal of the tumor and surrounding tissue during an operation. Surgery is the oldest and traditional type of cancer therapy, diagnosis, and remains an effective treatment for many

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Oparin-Haldane theory: Modern theory of the origin of life, Miller and Urey’s Experiment

Background: Different scientists and philosophers have put forwards different explanation of origin of life on earth from time to time. Some of the most popular hypotheses about the origin of life include the following: Introduction:  Stages:  This theory possesses three stages: Chemogeny Biogeny Cognogeny Oxygen revolution: Early atmosphere transform from reducing to oxidising and the

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Chemotherapy: Introduction, Classification, Types, Mode of action, Treatment Strategies

Introduction: Chemotherapy is the administration of one or more cytotoxic antineoplastic medications (chemotherapeutic agents) as part of a predetermined schedule to treat cancer. Chemotherapy may be administered with the intention of curing a disease, extending life, or alleviating symptoms. It is frequently used in conjunction with other treatments, such as radiation, surgery, and/or hyperthermia therapy.

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The Complement System: Introduction, Types, Functions

Introduction: The complement system is a part of immune system to protect the body from foreign particles that can damage the body. Initially, complement was defined as “the activity of blood serum that completes the action of antibody induce a series of inflammatory responses that help to fight infection”. At present, the complement system consists of over

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Genetic Maps:  Introduction, Linkage Maps, Cytogenetic Maps, Physical Maps

Introduction:  A genetic map is a schematic representation of the various genetic markers in the specific order in which they are located in a chromosome as well as the relative distances between these markers. Genetic mapping is the process of determining the physical position of a genetic component on chromosomes utilizing recombination and genetic markers.

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Biosensors: Introduction, Features, Components, Types, comparison, Applications

Introduction:  A biosensor is an analytical device, which employs a biological material to specifically interact an analyte; this interaction procedures some detectable physical change that is measured and converted into an electrical signal by a transducer. Finally, the electrical signal is amplified, interpreted, and displayed as analyte concentration in the solution/preparation. An analyte is a

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